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Clinical course of SUDV-infected IFNAR-/- mice.The experimental approach is shown in (A). Female (F) and male (M) IFNAR-/- mice were infected with approx. 1,000 PFU SUDV on day 0 (n = 6) and monitored daily. The mice were euthanized at humane clinical endpoint (score of ≥10 on one day or ≥6 on two consecutive days). Blood samples were collected at day 3, and on the day of euthanasia. The additive clinical score (B), summarizes the results of the different parameters analyzed daily: (C) body weight, behaviour, and appearance. Each parameter could be awarded a maximum of 10 points. Grey boxes indicate days after euthanasia. The relative body weight compared to day 0 for each mouse is depicted in (D). The dotted line marks the clinical endpoint. The Kaplan-Meier survival curve (E) depicts the percentage of surviving mice over time.
Public Health

Sudan virus inflammation in IFNAR-deficient mice

From the abstract: “C57BL/6J IFNAR-/- mice, which lack the type I interferon (IFN-α/β) receptor, have been reported to be susceptible to filovirus infections, although their impaired innate immune response may represent a potential limitation of the model.”

Editorial illustration: Adolescent sleep health in Africa: a research review
Public Health

Adolescent sleep health in Africa: a research review

From the abstract: “This review aimed to map the studies on adolescent sleep health in Africa with a focus on the geographical distribution, publication trends, pattern of sleep health measures, prevalence of sleep disorders, the barriers and facilitators to good sleep health, rural-urban disparities, as well as the associations of sleep health with mental health, school schedule and cardio-metabolic risk among the adolescents.”

Editorial illustration: Stakeholder views on improving emergency heart attack care in Tanzania
Research & Evidence

Stakeholder views on improving emergency heart attack care in Tanzania

From the abstract: “This qualitative study involved in-depth interviews with 20 key stakeholders (physicians, nurses, administrators, and patients diagnosed with AMI) who participated in MIMIC during the first year of implementation in the emergency department (ED) of a regional referral center in northern Tanzania.”