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Sudan

Clinical course of SUDV-infected IFNAR-/- mice.The experimental approach is shown in (A). Female (F) and male (M) IFNAR-/- mice were infected with approx. 1,000 PFU SUDV on day 0 (n = 6) and monitored daily. The mice were euthanized at humane clinical endpoint (score of ≥10 on one day or ≥6 on two consecutive days). Blood samples were collected at day 3, and on the day of euthanasia. The additive clinical score (B), summarizes the results of the different parameters analyzed daily: (C) body weight, behaviour, and appearance. Each parameter could be awarded a maximum of 10 points. Grey boxes indicate days after euthanasia. The relative body weight compared to day 0 for each mouse is depicted in (D). The dotted line marks the clinical endpoint. The Kaplan-Meier survival curve (E) depicts the percentage of surviving mice over time.
Public Health

Sudan virus inflammation in IFNAR-deficient mice

From the abstract: “C57BL/6J IFNAR-/- mice, which lack the type I interferon (IFN-α/β) receptor, have been reported to be susceptible to filovirus infections, although their impaired innate immune response may represent a potential limitation of the model.”